HbA1c Is Associated with Frailty in a Group of Aboriginal Australians.
Identifieur interne : 000918 ( Main/Exploration ); précédent : 000917; suivant : 000919HbA1c Is Associated with Frailty in a Group of Aboriginal Australians.
Auteurs : Z. Hyde [Australie] ; K. Smith ; L. Flicker ; D. Atkinson ; S. Fenner ; L. Skeaf ; R. Malay ; D. Lo GiudiceSource :
- The Journal of frailty & aging [ 2260-1341 ]
Descripteurs français
- KwdFr :
- MESH :
- analyse : Hémoglobine A glycosylée.
- ethnologie : Fragilité.
- sang : Fragilité.
- statistiques et données numériques : Population d'origine océanique.
- Adulte d'âge moyen, Australie, Facteurs de risque, Humains, Études transversales.
- Wicri :
- geographic : Australie.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Glycated Hemoglobin A.
- geographic : Australia.
- blood : Frailty.
- ethnology : Frailty.
- statistics & numerical data : Oceanic Ancestry Group.
- Cross-Sectional Studies, Humans, Middle Aged, Risk Factors.
Abstract
In this cross-sectional study of 141 Aboriginal Australians aged ≥45 years living in the remote Kimberley region of Western Australia, we explored whether glycated haemoglobin (HbA1c) levels were associated with frailty. Sixty-four participants (45.4%) had a HbA1c level ≥6.5% and 84 participants (59.6%) were frail. A significant trend was observed with regard to HbA1c levels and frailty, with those having HbA1c levels ≥6.5% having the greatest prevalence of frailty (70.3%). In binary logistic regression analyses, having a HbA1c level ≥6.5% was associated with being frail after adjustment for age, sex, and education. This association was attenuated after further adjustment for body mass index (BMI). Poorer glycaemic control is very common and a potential risk factor for frailty in remote-living Aboriginal Australians, and appears to be partly mediated by BMI, a known risk factor for diabetes mellitus. Obesity and diabetes mellitus are potentially important modifiable risk factors for frailty.
DOI: 10.14283/jfa.2018.41
PubMed: 30734826
Affiliations:
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Flicker</name></author><author><name sortKey="Atkinson, D" sort="Atkinson, D" uniqKey="Atkinson D" first="D" last="Atkinson">D. Atkinson</name></author><author><name sortKey="Fenner, S" sort="Fenner, S" uniqKey="Fenner S" first="S" last="Fenner">S. Fenner</name></author><author><name sortKey="Skeaf, L" sort="Skeaf, L" uniqKey="Skeaf L" first="L" last="Skeaf">L. Skeaf</name></author><author><name sortKey="Malay, R" sort="Malay, R" uniqKey="Malay R" first="R" last="Malay">R. Malay</name></author><author><name sortKey="Lo Giudice, D" sort="Lo Giudice, D" uniqKey="Lo Giudice D" first="D" last="Lo Giudice">D. Lo Giudice</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:30734826</idno><idno type="pmid">30734826</idno><idno type="doi">10.14283/jfa.2018.41</idno><idno type="wicri:Area/Main/Corpus">000A40</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000A40</idno><idno type="wicri:Area/Main/Curation">000A40</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000A40</idno><idno type="wicri:Area/Main/Exploration">000A40</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">HbA1c Is Associated with Frailty in a Group of Aboriginal Australians.</title><author><name sortKey="Hyde, Z" sort="Hyde, Z" uniqKey="Hyde Z" first="Z" last="Hyde">Z. Hyde</name><affiliation wicri:level="1"><nlm:affiliation>Prof Dina Lo Giudice, Department of Aged Care, Melbourne Health, Royal Park Campus, 34 Poplar Road, Parkville, Victoria 3052, Australia, E-mail: dina.logiudice@mh.org.au.</nlm:affiliation><country wicri:rule="url">Australie</country><wicri:regionArea>Prof Dina Lo Giudice, Department of Aged Care, Melbourne Health, Royal Park Campus, 34 Poplar Road, Parkville, Victoria 3052, Australia</wicri:regionArea><wicri:noRegion>Australia</wicri:noRegion></affiliation></author><author><name sortKey="Smith, K" sort="Smith, K" uniqKey="Smith K" first="K" last="Smith">K. Smith</name></author><author><name sortKey="Flicker, L" sort="Flicker, L" uniqKey="Flicker L" first="L" last="Flicker">L. Flicker</name></author><author><name sortKey="Atkinson, D" sort="Atkinson, D" uniqKey="Atkinson D" first="D" last="Atkinson">D. Atkinson</name></author><author><name sortKey="Fenner, S" sort="Fenner, S" uniqKey="Fenner S" first="S" last="Fenner">S. Fenner</name></author><author><name sortKey="Skeaf, L" sort="Skeaf, L" uniqKey="Skeaf L" first="L" last="Skeaf">L. Skeaf</name></author><author><name sortKey="Malay, R" sort="Malay, R" uniqKey="Malay R" first="R" last="Malay">R. Malay</name></author><author><name sortKey="Lo Giudice, D" sort="Lo Giudice, D" uniqKey="Lo Giudice D" first="D" last="Lo Giudice">D. Lo Giudice</name></author></analytic><series><title level="j">The Journal of frailty & aging</title><idno type="ISSN">2260-1341</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Australia (MeSH)</term><term>Cross-Sectional Studies (MeSH)</term><term>Frailty (blood)</term><term>Frailty (ethnology)</term><term>Glycated Hemoglobin A (analysis)</term><term>Humans (MeSH)</term><term>Middle Aged (MeSH)</term><term>Oceanic Ancestry Group (statistics & numerical data)</term><term>Risk Factors (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term><term>Australie (MeSH)</term><term>Facteurs de risque (MeSH)</term><term>Fragilité (ethnologie)</term><term>Fragilité (sang)</term><term>Humains (MeSH)</term><term>Hémoglobine A glycosylée (analyse)</term><term>Population d'origine océanique (statistiques et données numériques)</term><term>Études transversales (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Glycated Hemoglobin A</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Australia</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Hémoglobine A glycosylée</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Frailty</term></keywords><keywords scheme="MESH" qualifier="ethnologie" xml:lang="fr"><term>Fragilité</term></keywords><keywords scheme="MESH" qualifier="ethnology" xml:lang="en"><term>Frailty</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Fragilité</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Oceanic Ancestry Group</term></keywords><keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Population d'origine océanique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cross-Sectional Studies</term><term>Humans</term><term>Middle Aged</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Australie</term><term>Facteurs de risque</term><term>Humains</term><term>Études transversales</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Australie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In this cross-sectional study of 141 Aboriginal Australians aged ≥45 years living in the remote Kimberley region of Western Australia, we explored whether glycated haemoglobin (HbA1c) levels were associated with frailty. Sixty-four participants (45.4%) had a HbA1c level ≥6.5% and 84 participants (59.6%) were frail. A significant trend was observed with regard to HbA1c levels and frailty, with those having HbA1c levels ≥6.5% having the greatest prevalence of frailty (70.3%). In binary logistic regression analyses, having a HbA1c level ≥6.5% was associated with being frail after adjustment for age, sex, and education. This association was attenuated after further adjustment for body mass index (BMI). Poorer glycaemic control is very common and a potential risk factor for frailty in remote-living Aboriginal Australians, and appears to be partly mediated by BMI, a known risk factor for diabetes mellitus. Obesity and diabetes mellitus are potentially important modifiable risk factors for frailty.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">30734826</PMID><DateCompleted><Year>2019</Year><Month>07</Month><Day>01</Day></DateCompleted><DateRevised><Year>2019</Year><Month>07</Month><Day>01</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">2260-1341</ISSN><JournalIssue CitedMedium="Print"><Volume>8</Volume><Issue>1</Issue><PubDate><MedlineDate>2019</MedlineDate></PubDate></JournalIssue><Title>The Journal of frailty & aging</Title><ISOAbbreviation>J Frailty Aging</ISOAbbreviation></Journal><ArticleTitle>HbA1c Is Associated with Frailty in a Group of Aboriginal Australians.</ArticleTitle><Pagination><MedlinePgn>17-20</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.14283/jfa.2018.41</ELocationID><Abstract><AbstractText>In this cross-sectional study of 141 Aboriginal Australians aged ≥45 years living in the remote Kimberley region of Western Australia, we explored whether glycated haemoglobin (HbA1c) levels were associated with frailty. Sixty-four participants (45.4%) had a HbA1c level ≥6.5% and 84 participants (59.6%) were frail. A significant trend was observed with regard to HbA1c levels and frailty, with those having HbA1c levels ≥6.5% having the greatest prevalence of frailty (70.3%). In binary logistic regression analyses, having a HbA1c level ≥6.5% was associated with being frail after adjustment for age, sex, and education. This association was attenuated after further adjustment for body mass index (BMI). Poorer glycaemic control is very common and a potential risk factor for frailty in remote-living Aboriginal Australians, and appears to be partly mediated by BMI, a known risk factor for diabetes mellitus. Obesity and diabetes mellitus are potentially important modifiable risk factors for frailty.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hyde</LastName><ForeName>Z</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Prof Dina Lo Giudice, Department of Aged Care, Melbourne Health, Royal Park Campus, 34 Poplar Road, Parkville, Victoria 3052, Australia, E-mail: dina.logiudice@mh.org.au.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>K</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Flicker</LastName><ForeName>L</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Atkinson</LastName><ForeName>D</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Fenner</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Skeaf</LastName><ForeName>L</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Malay</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Lo Giudice</LastName><ForeName>D</ForeName><Initials>D</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>J Frailty Aging</MedlineTA><NlmUniqueID>101604797</NlmUniqueID><ISSNLinking>2260-1341</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006442">Glycated Hemoglobin A</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D001315" MajorTopicYN="N" Type="Geographic">Australia</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003430" MajorTopicYN="N">Cross-Sectional Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000073496" MajorTopicYN="N">Frailty</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000208" MajorTopicYN="Y">ethnology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006442" MajorTopicYN="N">Glycated Hemoglobin A</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D044468" MajorTopicYN="N">Oceanic Ancestry Group</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Frailty</Keyword><Keyword MajorTopicYN="N">aboriginal</Keyword><Keyword MajorTopicYN="N">ageing</Keyword><Keyword MajorTopicYN="N">diabetes</Keyword><Keyword MajorTopicYN="N">indigenous</Keyword></KeywordList><CoiStatement>The authors have received funding from the National Health and Medical Research Council (NHMRC) of Australia, as described below.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>2</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>2</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>7</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30734826</ArticleId><ArticleId IdType="doi">10.14283/jfa.2018.41</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li></country></list><tree><noCountry><name sortKey="Atkinson, D" sort="Atkinson, D" uniqKey="Atkinson D" first="D" last="Atkinson">D. Atkinson</name><name sortKey="Fenner, S" sort="Fenner, S" uniqKey="Fenner S" first="S" last="Fenner">S. Fenner</name><name sortKey="Flicker, L" sort="Flicker, L" uniqKey="Flicker L" first="L" last="Flicker">L. Flicker</name><name sortKey="Lo Giudice, D" sort="Lo Giudice, D" uniqKey="Lo Giudice D" first="D" last="Lo Giudice">D. Lo Giudice</name><name sortKey="Malay, R" sort="Malay, R" uniqKey="Malay R" first="R" last="Malay">R. Malay</name><name sortKey="Skeaf, L" sort="Skeaf, L" uniqKey="Skeaf L" first="L" last="Skeaf">L. Skeaf</name><name sortKey="Smith, K" sort="Smith, K" uniqKey="Smith K" first="K" last="Smith">K. Smith</name></noCountry><country name="Australie"><noRegion><name sortKey="Hyde, Z" sort="Hyde, Z" uniqKey="Hyde Z" first="Z" last="Hyde">Z. Hyde</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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